Journal: Epigenetics
Article Title: Placental and immune cell DNA methylation reference panel for bulk tissue cell composition estimation in epidemiological studies
doi: 10.1080/15592294.2024.2437275
Figure Lengend Snippet: Top differentially methylated sites unique to the five placental cell types (cytotrophoblast, endothelial, Hofbauer, stromal, and syncytiotrophoblast) and nucleated red blood cells with gene annotations reveal highly specific DNA methylation profiles by cell type.
Article Snippet: To assess the performance of our placental DNA methylation deconvolution reference, we compared its ability to predict DNA methylation variation [ ] in a preprocessed placental whole tissue Illumina EPIC microarray DNA methylation dataset comprising 204 placentas across three cohorts (GEO accession number GSE232778) [ ] against the only existing multi-cell type reference [ ].
Techniques: Methylation, DNA Methylation Assay